Head and Neck cancer is the most common cancer worldwide. The incidence of the disease has a strong positive correlation with the patients’ ages. Approximately 85% of the male patients with this illness are older than 45. Smoking, tobacco, and alcohol intake are the primary risk features for head and neck cancer. The purpose of this study is to estimate the economic burden of male head and neck cancer disease. Head and neck cancer places a severe financial impact on households. To examine the impact of head and neck cancer on patients, we got the list of the patients from the territory care hospitals in Peshawar and interviewed 235 patients to estimate the health cost. The study’s methodology is divided into two parts: empirical estimations and descriptive statistics. The Ordinary Least Square (OLS) estimate technique was employed in the study to identify the variables affecting the expense of head and neck cancer. According to the analysis, the stage of cancer and the length of the treatment is increasing the cost of head and neck cancer and the number of cancer patients visiting these hospitals from the KPK, Islamabad, etc. The majority of respondents reported significant intangible burdens, such as fear, pain, mental distress, and family management. Patients with head and neck cancer were more likely to face several psychological issues because of their health condition.